One of the regular cast of the early John Waters movies, known collectively as the Dreamlanders, Susan Walsh made her first appearance in Mondo Trasho (1969). She went on to appear in Multiple Maniacs (1970), Pink Flamingos (1972)—where she showed off her rackage—and Female Trouble (1974). Susan also appeared in the John Waters documentary Divine Trash. Almost thirty years later, Susan returned to acting with a single appearance in the 2003 thriller Go-Go Motel, which was filmed in Baltimore.